No definition available.
Immunodeficiency with predominantly antibody defects
DOID EFO Endpoint Browser PheWeb
D3_IMMUDEFANTIBODY
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
850 |
4. Check minimum number of eventsNone |
850 |
5. Include endpoints |
872 |
6. Filter based on genotype QC (FinnGen only) |
830 |
Control definitions (FinnGen only)
Control exclude
D3_IMMUNEMECHANISM
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D80-D89
Name in latin
Deficientia immunalis praecipue cum vitiis anticorporum
Similar endpoints
↥List of similar endpoints to
Immunodeficiency with predominantly antibody defects
based on the number of shared cases.
Similar with more cases:
- Immunodeficiencies
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4354 | 2534 | 1806 |
| Only index persons | 3907 | 2323 | 1584 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.07 | 0.05 |
| Only index persons | 0.08 | 0.09 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 41.53 | 44.86 | 36.81 |
| Only index persons | 41.99 | 45.45 | 36.90 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 830 | 550 | 280 |
| Unadjusted period prevalence (%) | 0.19 | 0.22 | 0.14 |
| Median age at first event (years) | 48.51 | 47.08 | 51.34 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint D3_IMMUDEFANTIBODY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_IMMUDEFANTIBODY | 2.903 [2.37, 3.55] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.301 |
During the follow-up period (1.1.1998 — 31.12.2019), 305 out of 2102 females with D3_IMMUDEFANTIBODY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_IMMUDEFANTIBODY | 2.794 [2.15, 3.63] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 231 out of 1401 males with D3_IMMUDEFANTIBODY died.
Mortality risk
Mortality risk for people of age
years, who have D3_IMMUDEFANTIBODY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.329% | 0.461% |
| 5 | 1.814% | 2.947% |
| 10 | 4.576% | 7.651% |
| 15 | 8.876% | 13.489% |
| 20 | 14.553% | 22.313% |
Relationships between endpoints
↥Index endpoint: D3_IMMUDEFANTIBODY – Immunodeficiency with predominantly antibody defects
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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