No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
333 |
4. Check minimum number of eventsNone |
333 |
5. Include endpointsNone |
333 |
6. Filter based on genotype QC (FinnGen only) |
321 |
Control definitions (FinnGen only)
Control exclude
D3_IMMUNEMECHANISM
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D80
Name in latin
Hypogammaglobulinaemia non familialis
Similar endpoints
↥List of similar endpoints to
Nonhereditary hypogammaglobulinemia
based on the number of shared cases.
Similar with more cases:
- Immunodeficiency with predominantly antibody defects
- Immunodeficiencies
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1373 | 825 | 543 |
| Only index persons | 1282 | 786 | 496 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 50.05 | 52.53 | 46.32 |
| Only index persons | 49.45 | 52.05 | 45.35 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 321 | 210 | 111 |
| Unadjusted period prevalence (%) | 0.07 | 0.08 | 0.06 |
| Median age at first event (years) | 50.99 | 49.88 | 53.10 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint D3_NONHEREDHYPOGAMMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_NONHEREDHYPOGAMMA | 3.869 [3.03, 4.95] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.063 |
During the follow-up period (1.1.1998 — 31.12.2019), 147 out of 714 females with D3_NONHEREDHYPOGAMMA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_NONHEREDHYPOGAMMA | 3.065 [2.24, 4.19] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 99 out of 457 males with D3_NONHEREDHYPOGAMMA died.
Mortality risk
Mortality risk for people of age
years, who have D3_NONHEREDHYPOGAMMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.361% | 0.457% |
| 5 | 2.14% | 3.087% |
| 10 | 5.093% | 8.232% |
| 15 | 9.046% | 16.041% |
| 20 | 15.845% | 25.789% |
Relationships between endpoints
↥Index endpoint: D3_NONHEREDHYPOGAMMA – Nonhereditary hypogammaglobulinemia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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