No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
1657 |
6. Filter based on genotype QC (FinnGen only) |
1580 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Immunodeficiencies
based on the number of shared cases.
Similar with more cases:
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10839 | 6244 | 4540 |
| Only index persons | 9278 | 5498 | 3780 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.18 | 0.13 |
| Only index persons | 0.18 | 0.20 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 48.68 | 49.36 | 47.54 |
| Only index persons | 47.60 | 48.42 | 46.40 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1580 | 1011 | 569 |
| Unadjusted period prevalence (%) | 0.36 | 0.40 | 0.29 |
| Median age at first event (years) | 50.07 | 47.53 | 54.59 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint D3_IMMUDEF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_IMMUDEF | 2.207 [1.97, 2.48] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.33 |
During the follow-up period (1.1.1998 — 31.12.2019), 1143 out of 5305 females with D3_IMMUDEF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_IMMUDEF | 2.277 [1.99, 2.6] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.016 |
During the follow-up period (1.1.1998 — 31.12.2019), 1047 out of 3714 males with D3_IMMUDEF died.
Mortality risk
Mortality risk for people of age
years, who have D3_IMMUDEF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.213% | 0.443% |
| 5 | 1.299% | 2.692% |
| 10 | 3.201% | 6.61% |
| 15 | 6.311% | 12.155% |
| 20 | 10.873% | 20.671% |
Relationships between endpoints
↥Index endpoint: D3_IMMUDEF – Immunodeficiencies
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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