No definition available.
Other and unspecified immunodeficiencies with predominantly antibody defects
DOID EFO Endpoint Browser PheWeb
D3_IMMUDEFANTIBODYNAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
404 |
4. Check minimum number of eventsNone |
404 |
5. Include endpointsNone |
404 |
6. Filter based on genotype QC (FinnGen only) |
388 |
Control definitions (FinnGen only)
Control exclude
D3_IMMUNEMECHANISM
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified immunodeficiencies with predominantly antibody defects
based on the number of shared cases.
Similar with more cases:
- Immunodeficiency with predominantly antibody defects
- Immunodeficiencies
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1635 | 939 | 695 |
| Only index persons | 1497 | 874 | 623 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 44.50 | 48.34 | 39.35 |
| Only index persons | 44.51 | 48.28 | 39.22 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 388 | 257 | 131 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.07 |
| Median age at first event (years) | 49.29 | 48.85 | 50.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint D3_IMMUDEFANTIBODYNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_IMMUDEFANTIBODYNAS | 3.692 [2.74, 4.98] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.678 |
During the follow-up period (1.1.1998 — 31.12.2019), 114 out of 759 females with D3_IMMUDEFANTIBODYNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_IMMUDEFANTIBODYNAS | 4.194 [2.91, 6.04] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 101 out of 537 males with D3_IMMUDEFANTIBODYNAS died.
Mortality risk
Mortality risk for people of age
years, who have D3_IMMUDEFANTIBODYNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.49% | 0.783% |
| 5 | 2.474% | 4.738% |
| 10 | 6.1% | 11.305% |
| 15 | 11.228% | 20.533% |
| 20 | 18.82% | 33.16% |
Relationships between endpoints
↥Index endpoint: D3_IMMUDEFANTIBODYNAS – Other and unspecified immunodeficiencies with predominantly antibody defects
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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