Kela reimbursement Agammaglobulinemia (D80-84)

D3_KELA_IMMUDEF

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • KELA reimbursements: KELA codes 120

1 out of 7 registries used, show all original rules.

258

4. Check minimum number of events

None

258

5. Include endpoints

None

258

6. Filter based on genotype QC (FinnGen only)

246

Control definitions (FinnGen only)

Control exclude D3_IMMUNEMECHANISM

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 979 566 411
Only index persons 863 510 353
Unadjusted period prevalence (%)
Whole population 0.01 0.02 0.01
Only index persons 0.02 0.02 0.01
Median age at first event (years)
Whole population 42.67 45.86 38.29
Only index persons 41.96 46.26 35.76

-FinnGen-

Key figures

All Female Male
Number of individuals 246 158 88
Unadjusted period prevalence (%) 0.06 0.06 0.04
Median age at first event (years) 44.28 45.84 41.48

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint D3_KELA_IMMUDEF and mortality.

Females

Parameter HR [95% CI] p-value
D3_KELA_IMMUDEF 5.013 [3.21, 7.83] < 0.001
Birth year 0.998 [0.99, 1.01] 0.595

During the follow-up period (1.1.1998 — 31.12.2019), 53 out of 416 females with D3_KELA_IMMUDEF died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have D3_KELA_IMMUDEF.

N-year risk Females Males
1 0.44% No data
5 3.202% No data
10 7.618% No data
15 14.22% No data
20 23.763% No data

Relationships between endpoints

Index endpoint: D3_KELA_IMMUDEF – Kela reimbursement Agammaglobulinemia (D80-84)

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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