No definition available.
Immunodeficiency associated with other major defects
D3_IMMUDEFWITHMAJORDEF
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints |
84 |
6. Filter based on genotype QC (FinnGen only) |
79 |
Control definitions (FinnGen only)
Control exclude
D3_IMMUNEMECHANISM
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D80-D89
Name in latin
Deficientia immunalis cum aliis defectibus majoribus
Similar endpoints
↥List of similar endpoints to
Immunodeficiency associated with other major defects
based on the number of shared cases.
Similar with more cases:
- Immunodeficiencies
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 728 | 368 | 358 |
| Only index persons | 577 | 295 | 282 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 40.88 | 42.53 | 39.01 |
| Only index persons | 41.82 | 43.29 | 40.28 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 79 | 40 | 39 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 47.08 | 44.98 | 49.22 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint D3_IMMUDEFWITHMAJORDEF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_IMMUDEFWITHMAJORDEF | 2.935 [1.94, 4.44] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.289 |
During the follow-up period (1.1.1998 — 31.12.2019), 66 out of 294 females with D3_IMMUDEFWITHMAJORDEF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_IMMUDEFWITHMAJORDEF | 2.666 [1.66, 4.28] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 293 males with D3_IMMUDEFWITHMAJORDEF died.
Mortality risk
Mortality risk for people of age
years, who have D3_IMMUDEFWITHMAJORDEF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.285% | 0.428% |
| 5 | 1.877% | 2.813% |
| 10 | 4.685% | 6.763% |
| 15 | 8.607% | 13.305% |
| 20 | 14.179% | 21.391% |
Relationships between endpoints
↥Index endpoint: D3_IMMUDEFWITHMAJORDEF – Immunodeficiency associated with other major defects
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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