No definition available.
Selective deficiency of immunoglobulin G [IgG] subclasses
DOID EFO Endpoint Browser PheWeb
D3_DEF_IGG
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
222 |
4. Check minimum number of eventsNone |
222 |
5. Include endpointsNone |
222 |
6. Filter based on genotype QC (FinnGen only) |
213 |
Control definitions (FinnGen only)
Control exclude
D3_IMMUNEMECHANISM
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D80
Name in latin
Deficientia selectiva subclassium immunoglobulini G
Similar endpoints
↥List of similar endpoints to
Selective deficiency of immunoglobulin G [IgG] subclasses
based on the number of shared cases.
Similar with more cases:
- Immunodeficiency with predominantly antibody defects
- Immunodeficiencies
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1014 | 665 | 344 |
| Only index persons | 956 | 637 | 319 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 43.56 | 45.95 | 38.66 |
| Only index persons | 44.64 | 46.75 | 40.42 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 213 | 156 | 57 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | 47.77 | 47.66 | 48.07 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint D3_DEF_IGG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_DEF_IGG | 2.525 [1.85, 3.45] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.938 |
During the follow-up period (1.1.1998 — 31.12.2019), 72 out of 613 females with D3_DEF_IGG died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have D3_DEF_IGG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.284% | No data |
| 5 | 1.813% | No data |
| 10 | 4.498% | No data |
| 15 | 8.646% | No data |
| 20 | 14.401% | No data |
Relationships between endpoints
↥Index endpoint: D3_DEF_IGG – Selective deficiency of immunoglobulin G [IgG] subclasses
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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