No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
113 |
4. Check minimum number of eventsNone |
113 |
5. Include endpointsNone |
113 |
6. Filter based on genotype QC (FinnGen only) |
110 |
Control definitions (FinnGen only)
Control exclude
D3_IMMUNEMECHANISM
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D80
Name in latin
Hypogammaglobulinaemia hereditaria
Similar endpoints
↥List of similar endpoints to
Hereditary hypogammaglobulinemia
based on the number of shared cases.
Similar with more cases:
- Immunodeficiency with predominantly antibody defects
- Immunodeficiencies
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 605 | 359 | 244 |
| Only index persons | 530 | 325 | 205 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 42.72 | 45.82 | 38.04 |
| Only index persons | 42.31 | 45.45 | 37.32 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 110 | 71 | 39 |
| Unadjusted period prevalence (%) | 0.02 | 0.03 | 0.02 |
| Median age at first event (years) | 47.16 | 47.68 | 46.22 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint D3_HEREDHYPOGAMMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HEREDHYPOGAMMA | 3.534 [2.19, 5.71] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.052 |
During the follow-up period (1.1.1998 — 31.12.2019), 61 out of 290 females with D3_HEREDHYPOGAMMA died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have D3_HEREDHYPOGAMMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.309% | No data |
| 5 | 1.859% | No data |
| 10 | 4.472% | No data |
| 15 | 8.584% | No data |
| 20 | 14.501% | No data |
Relationships between endpoints
↥Index endpoint: D3_HEREDHYPOGAMMA – Hereditary hypogammaglobulinemia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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