obsolete_sarcoidosis: ['An idiopathic inflammatory disorder characterized by the formation of non-necrotizing epithelioid granulomas which contain giant cells. It usually affects the lungs, lymph nodes, liver, and skin.', 'An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
5000 |
4. Check minimum number of eventsNone |
5000 |
5. Include endpointsNone |
5000 |
6. Filter based on genotype QC (FinnGen only) |
4854 |
Control definitions (FinnGen only)
Control exclude
D3_IMMUNEMECHANISM
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D80-D89
Name in latin
Sarcoidosis
Similar endpoints
↥List of similar endpoints to
Sarcoidosis
based on the number of shared cases.
Similar with more cases:
- Certain disorders involving the immune mechanism
- Diagnoses used for exclusion with ILD
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Excluding asthma or asthma-COPD overlap
- COPD differential diagnosis
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 34942 | 18933 | 15788 |
| Only index persons | 30759 | 16617 | 14142 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.49 | 0.54 | 0.44 |
| Only index persons | 0.58 | 0.61 | 0.54 |
| Median age at first event (years) | |||
| Whole population | 46.39 | 49.71 | 42.37 |
| Only index persons | 45.23 | 48.24 | 41.69 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4854 | 2732 | 2122 |
| Unadjusted period prevalence (%) | 1.07 | 1.07 | 1.07 |
| Median age at first event (years) | 46.67 | 48.16 | 44.76 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint D3_SARCOIDOSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_SARCOIDOSIS | 1.39 [1.25, 1.54] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.711 |
During the follow-up period (1.1.1998 — 31.12.2019), 1208 out of 9966 females with D3_SARCOIDOSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_SARCOIDOSIS | 1.389 [1.25, 1.54] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 1134 out of 8918 males with D3_SARCOIDOSIS died.
Mortality risk
Mortality risk for people of age
years, who have D3_SARCOIDOSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.134% | 0.329% |
| 5 | 0.738% | 1.766% |
| 10 | 2.088% | 3.93% |
| 15 | 4.361% | 7.144% |
| 20 | 7.682% | 12.149% |
Relationships between endpoints
↥Index endpoint: D3_SARCOIDOSIS – Sarcoidosis
GWS hits: 14
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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