nephritis: Inflammation of renal tissue. [ NCIT:P378 ]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
739 |
4. Check minimum number of eventsNone |
739 |
5. Include endpointsNone |
739 |
6. Filter based on genotype QC (FinnGen only) |
716 |
Control definitions (FinnGen only)
Control exclude
N14_GLOMERULAR
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N00-N08
Name in latin
Syndroma nephriticum non specificatum
Similar endpoints
↥List of similar endpoints to
Unspecified nephritic syndrome
based on the number of shared cases.
Similar with more cases:
- Glomerulonephritis
- Glomerular diseases
- Genitourinary diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8239 | 3572 | 4519 |
| Only index persons | 5566 | 2532 | 3034 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.10 | 0.13 |
| Only index persons | 0.11 | 0.09 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 45.73 | 49.89 | 41.98 |
| Only index persons | 36.87 | 40.89 | 33.51 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 716 | 325 | 391 |
| Unadjusted period prevalence (%) | 0.17 | 0.13 | 0.20 |
| Median age at first event (years) | 37.33 | 36.84 | 37.73 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint N14_NEPHRITICNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_NEPHRITICNAS | 3.223 [2.74, 3.79] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.267 |
During the follow-up period (1.1.1998 — 31.12.2019), 526 out of 1505 females with N14_NEPHRITICNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_NEPHRITICNAS | 3.306 [2.74, 3.99] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 460 out of 1344 males with N14_NEPHRITICNAS died.
Mortality risk
Mortality risk for people of age
years, who have N14_NEPHRITICNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.254% | 0.593% |
| 5 | 1.766% | 3.965% |
| 10 | 4.829% | 9.347% |
| 15 | 9.355% | 16.734% |
| 20 | 15.551% | 27.301% |
Relationships between endpoints
↥Index endpoint: N14_NEPHRITICNAS – Unspecified nephritic syndrome
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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