No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
3708 |
6. Filter based on genotype QC (FinnGen only) |
3556 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF10
Glomerulonephritis
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 33734 | 14344 | 18890 |
| Only index persons | 24574 | 10882 | 13692 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.48 | 0.41 | 0.53 |
| Only index persons | 0.47 | 0.40 | 0.52 |
| Median age at first event (years) | |||
| Whole population | 46.70 | 47.63 | 45.69 |
| Only index persons | 39.69 | 40.49 | 39.06 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3556 | 1555 | 2001 |
| Unadjusted period prevalence (%) | 0.83 | 0.61 | 1.00 |
| Median age at first event (years) | 42.82 | 38.43 | 46.23 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_GLOMER_NEPHRITIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_GLOMER_NEPHRITIS | 2.851 [2.56, 3.17] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.301 |
During the follow-up period (1.1.1998 — 31.12.2019), 2208 out of 7631 females with N14_GLOMER_NEPHRITIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_GLOMER_NEPHRITIS | 2.795 [2.51, 3.11] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 3063 out of 8544 males with N14_GLOMER_NEPHRITIS died.
Mortality risk
Mortality risk for people of age
years, who have N14_GLOMER_NEPHRITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.276% | 0.449% |
| 5 | 1.592% | 2.783% |
| 10 | 4.124% | 7.175% |
| 15 | 7.835% | 13.579% |
| 20 | 14.313% | 22.009% |
Relationships between endpoints
↥Index endpoint: N14_GLOMER_NEPHRITIS – Glomerulonephritis
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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