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Acute nephritic syndrome

DOID EFO Endpoint Browser PheWeb

N14_ACUTENEPHRITIC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — N00#
  • Hospital discharge: ICD-9 — 580
  • Hospital discharge: ICD-8 — 580
  • Hospital discharge: excluded ICD-9 — 5804
  • Cause of death: ICD-10 — N00#
  • Cause of death: ICD-9 — 580
  • Cause of death: ICD-8 — 580
  • Cause of death: excluded ICD-9 — 5804

2 out of 7 registries used, show all original rules.

732

4. Check minimum number of events

None

732

5. Include endpoints

None

732

6. Filter based on genotype QC (FinnGen only)

698

Control definitions (FinnGen only)

Control exclude N14_GLOMERULAR

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 N00-N08
Name in latin Syndroma nephriticum acutum

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6888 2571 4253
Only index persons 5423 2070 3353
Unadjusted period prevalence (%)
Whole population 0.10 0.07 0.12
Only index persons 0.11 0.08 0.13
Median age at first event (years)
Whole population 33.02 34.02 32.14
Only index persons 28.39 28.38 28.39

-FinnGen-

Key figures

All Female Male
Number of individuals 698 283 415
Unadjusted period prevalence (%) 0.17 0.11 0.21
Median age at first event (years) 31.42 28.90 33.14

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint N14_ACUTENEPHRITIC and mortality.

Females

Parameter HR [95% CI] p-value
N14_ACUTENEPHRITIC 2.352 [1.85, 2.99] < 0.001
Birth year 0.997 [0.99, 1.01] 0.542

During the follow-up period (1.1.1998 — 31.12.2019), 218 out of 1006 females with N14_ACUTENEPHRITIC died.

Males

Parameter HR [95% CI] p-value
N14_ACUTENEPHRITIC 2.225 [1.81, 2.73] < 0.001
Birth year 0.991 [0.98, 1.0] 0.05

During the follow-up period (1.1.1998 — 31.12.2019), 333 out of 1234 males with N14_ACUTENEPHRITIC died.

Mortality risk

Mortality risk for people of age

years, who have N14_ACUTENEPHRITIC.

N-year risk Females Males
1 0.177% 0.529%
5 1.543% 3.105%
10 3.692% 7.535%
15 6.689% 13.671%
20 11.881% 22.28%

Relationships between endpoints

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Index endpoint: N14_ACUTENEPHRITIC – Acute nephritic syndrome

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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