Recurrent and persistent haematuria

N14_RECURANDPERHEAMATUR

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N02#
  • Cause of death: ICD-10 N02#

2 out of 7 registries used, show all original rules.

274

4. Check minimum number of events

None

274

5. Include endpoints

None

274

6. Filter based on genotype QC (FinnGen only)

264

Control definitions (FinnGen only)

Control exclude N14_GLOMERULAR

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 N00-N08
Name in latin Haematuria recidiva et persistens

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2501 1150 1325
Only index persons 2128 1044 1084
Unadjusted period prevalence (%)
Whole population 0.04 0.03 0.04
Only index persons 0.04 0.04 0.04
Median age at first event (years)
Whole population 52.05 43.41 59.18
Only index persons 48.62 41.87 55.11

-FinnGen-

Key figures

All Female Male
Number of individuals 264 119 145
Unadjusted period prevalence (%) 0.06 0.05 0.07
Median age at first event (years) 52.89 43.30 60.76

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint N14_RECURANDPERHEAMATUR and mortality.

Females

Parameter HR [95% CI] p-value
N14_RECURANDPERHEAMATUR 2.32 [1.83, 2.94] < 0.001
Birth year 0.992 [0.98, 1.0] 0.11

During the follow-up period (1.1.1998 — 31.12.2019), 187 out of 1005 females with N14_RECURANDPERHEAMATUR died.

Males

Parameter HR [95% CI] p-value
N14_RECURANDPERHEAMATUR 2.256 [1.73, 2.94] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 422 out of 1118 males with N14_RECURANDPERHEAMATUR died.

Mortality risk

Mortality risk for people of age

years, who have N14_RECURANDPERHEAMATUR.

N-year risk Females Males
1 0.215% 0.347%
5 1.295% 2.358%
10 3.217% 5.811%
15 5.868% 11.113%
20 10.82% 18.533%

Relationships between endpoints

Index endpoint: N14_RECURANDPERHEAMATUR – Recurrent and persistent haematuria

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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