No definition available.
Isolated proteinuria with specified morphological lesion
DOID EFO Endpoint Browser PheWeb
N14_ISOLPROTEINURIA
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
358 |
4. Check minimum number of eventsNone |
358 |
5. Include endpointsNone |
358 |
6. Filter based on genotype QC (FinnGen only) |
342 |
Control definitions (FinnGen only)
Control exclude
N14_GLOMERULAR
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N00-N08
Name in latin
Proteinuria isolata cum laesione morphologica specificata
Similar endpoints
↥List of similar endpoints to
Isolated proteinuria with specified morphological lesion
based on the number of shared cases.
Similar with more cases:
- Glomerulonephritis
- Glomerular diseases
- Genitourinary diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2409 | 1167 | 1221 |
| Only index persons | 2118 | 1030 | 1088 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 57.83 | 56.49 | 59.16 |
| Only index persons | 55.61 | 53.58 | 57.53 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 342 | 165 | 177 |
| Unadjusted period prevalence (%) | 0.08 | 0.06 | 0.09 |
| Median age at first event (years) | 56.07 | 50.19 | 61.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint N14_ISOLPROTEINURIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_ISOLPROTEINURIA | 2.374 [1.89, 2.99] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.498 |
During the follow-up period (1.1.1998 — 31.12.2019), 298 out of 1035 females with N14_ISOLPROTEINURIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_ISOLPROTEINURIA | 2.47 [2.05, 2.98] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 335 out of 1068 males with N14_ISOLPROTEINURIA died.
Mortality risk
Mortality risk for people of age
years, who have N14_ISOLPROTEINURIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.206% | 0.406% |
| 5 | 1.226% | 2.37% |
| 10 | 3.842% | 6.592% |
| 15 | 7.307% | 12.895% |
| 20 | 13.146% | 21.264% |
Relationships between endpoints
↥Index endpoint: N14_ISOLPROTEINURIA – Isolated proteinuria with specified morphological lesion
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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