No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
87 |
4. Check minimum number of eventsNone |
87 |
5. Include endpointsNone |
87 |
6. Filter based on genotype QC (FinnGen only) |
84 |
Control definitions (FinnGen only)
Control exclude
N14_GLOMERULAR
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N00-N08
Name in latin
Nephropathia hereditaria non alibi classificata
Similar endpoints
↥List of similar endpoints to
Hereditary nephropathy, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Glomerulonephritis
- Glomerular diseases
- Genitourinary diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 696 | 397 | 292 |
| Only index persons | 604 | 359 | 245 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 56.77 | 56.15 | 57.22 |
| Only index persons | 54.59 | 53.86 | 55.65 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 84 | 42 | 42 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 58.42 | 55.95 | 60.90 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint N14_NEPHROPATHYHER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_NEPHROPATHYHER | 1.877 [1.41, 2.5] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.831 |
During the follow-up period (1.1.1998 — 31.12.2019), 104 out of 364 females with N14_NEPHROPATHYHER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_NEPHROPATHYHER | 2.079 [1.56, 2.77] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 265 males with N14_NEPHROPATHYHER died.
Mortality risk
Mortality risk for people of age
years, who have N14_NEPHROPATHYHER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.211% | 0.338% |
| 5 | 1.2% | 2.306% |
| 10 | 3.01% | 5.455% |
| 15 | 5.937% | 10.541% |
| 20 | 10.864% | 17.371% |
Relationships between endpoints
↥Index endpoint: N14_NEPHROPATHYHER – Hereditary nephropathy, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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