No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
74 |
4. Check minimum number of eventsNone |
74 |
5. Include endpointsNone |
74 |
6. Filter based on genotype QC (FinnGen only) |
70 |
Control definitions (FinnGen only)
Control exclude
N14_GLOMERULAR
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N00-N08
Name in latin
Syndroma nephriticum cito progrediens
Similar endpoints
↥List of similar endpoints to
Rapidly progressive nephritic syndrome
based on the number of shared cases.
Similar with more cases:
- Glomerulonephritis
- Glomerular diseases
- Genitourinary diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 618 | 323 | 291 |
| Only index persons | 464 | 246 | 218 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 58.72 | 58.87 | 58.31 |
| Only index persons | 52.82 | 52.51 | 53.16 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 70 | 35 | 35 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 57.83 | 52.84 | 62.81 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint N14_RAPIDPROGNEPHRITIC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_RAPIDPROGNEPHRITIC | 2.733 [1.89, 3.96] | < 0.001 |
| Birth year | 0.994 [0.98, 1.0] | 0.144 |
During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 252 females with N14_RAPIDPROGNEPHRITIC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_RAPIDPROGNEPHRITIC | 3.037 [1.91, 4.83] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 98 out of 231 males with N14_RAPIDPROGNEPHRITIC died.
Mortality risk
Mortality risk for people of age
years, who have N14_RAPIDPROGNEPHRITIC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.228% | 0.493% |
| 5 | 1.488% | 3.599% |
| 10 | 3.874% | 8.098% |
| 15 | 7.352% | 15.216% |
| 20 | 12.18% | 24.741% |
Relationships between endpoints
↥Index endpoint: N14_RAPIDPROGNEPHRITIC – Rapidly progressive nephritic syndrome
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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