nephrotic syndrome: A collection of symptoms that include severe edema, proteinuria, and hypoalbuminemia; it is indicative of renal dysfunction.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1068 |
4. Check minimum number of eventsNone |
1068 |
5. Include endpointsNone |
1068 |
6. Filter based on genotype QC (FinnGen only) |
1008 |
Control definitions (FinnGen only)
Control exclude
N14_GLOMERULAR
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N00-N08
Name in latin
Syndroma nephroticum
Similar endpoints
↥List of similar endpoints to
Nephrotic syndrome
based on the number of shared cases.
Similar with more cases:
- Glomerulonephritis
- Glomerular diseases
- Genitourinary diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7991 | 3363 | 4520 |
| Only index persons | 6080 | 2628 | 3452 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.10 | 0.13 |
| Only index persons | 0.12 | 0.10 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 50.10 | 49.08 | 50.66 |
| Only index persons | 45.52 | 43.36 | 47.16 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1008 | 418 | 590 |
| Unadjusted period prevalence (%) | 0.24 | 0.16 | 0.30 |
| Median age at first event (years) | 47.93 | 40.27 | 53.35 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_NEPHROTICSYND and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_NEPHROTICSYND | 3.48 [2.92, 4.15] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.035 |
During the follow-up period (1.1.1998 — 31.12.2019), 568 out of 2059 females with N14_NEPHROTICSYND died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_NEPHROTICSYND | 3.206 [2.77, 3.72] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.029 |
During the follow-up period (1.1.1998 — 31.12.2019), 976 out of 2797 males with N14_NEPHROTICSYND died.
Mortality risk
Mortality risk for people of age
years, who have N14_NEPHROTICSYND.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.276% | 0.78% |
| 5 | 1.842% | 4.366% |
| 10 | 4.395% | 10.506% |
| 15 | 8.503% | 18.736% |
| 20 | 13.598% | 30.558% |
Relationships between endpoints
↥Index endpoint: N14_NEPHROTICSYND – Nephrotic syndrome
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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