nephritis: Inflammation of renal tissue. [ NCIT:P378 ]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1360 |
4. Check minimum number of eventsNone |
1360 |
5. Include endpointsNone |
1360 |
6. Filter based on genotype QC (FinnGen only) |
1307 |
Control definitions (FinnGen only)
Extra metadata
Similar endpoints
↥List of similar endpoints to Chronic nephritic syndrome based on the number of shared cases.
Similar with more cases:
- Glomerulonephritis
- Glomerular diseases
- Genitourinary diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 11680 | 4699 | 6744 |
Only index persons | 7799 | 3375 | 4424 |
Unadjusted period prevalence (%) | |||
Whole population | 0.17 | 0.13 | 0.19 |
Only index persons | 0.15 | 0.12 | 0.17 |
Median age at first event (years) | |||
Whole population | 50.03 | 48.25 | 51.03 |
Only index persons | 43.31 | 41.25 | 44.89 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 1307 | 542 | 765 |
Unadjusted period prevalence (%) | 0.31 | 0.21 | 0.38 |
Median age at first event (years) | 43.88 | 37.88 | 48.13 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_CHRONEPHROPATH and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
N14_CHRONEPHROPATH | 2.953 [2.51, 3.47] | < 0.001 |
Birth year | 0.992 [0.98, 1.0] | 0.075 |
During the follow-up period (1.1.1998 — 31.12.2019), 650 out of 2317 females with N14_CHRONEPHROPATH died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
N14_CHRONEPHROPATH | 2.713 [2.41, 3.06] | < 0.001 |
Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 1145 out of 3091 males with N14_CHRONEPHROPATH died.
Mortality risk
Mortality risk for people of age
years, who have N14_CHRONEPHROPATH.N-year risk | Females | Males |
---|---|---|
1 | 0.326% | 0.519% |
5 | 1.781% | 3.095% |
10 | 4.435% | 7.277% |
15 | 8.103% | 13.566% |
20 | 13.509% | 22.233% |
Relationships between endpoints
↥Index endpoint: N14_CHRONEPHROPATH – Chronic nephritic syndrome
GWS hits: 1