No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
49441 |
4. Check minimum number of eventsNone |
49441 |
5. Include endpoints |
172867 |
6. Filter based on genotype QC (FinnGen only) |
165261 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF10
Diseases of oral cavity, salivary glands and jaws
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1617851 | 861854 | 744809 |
| Only index persons | 1540732 | 832261 | 708471 |
| Unadjusted period prevalence (%) | |||
| Whole population | 22.81 | 24.69 | 20.81 |
| Only index persons | 28.96 | 30.60 | 27.04 |
| Median age at first event (years) | |||
| Whole population | 40.11 | 40.94 | 39.24 |
| Only index persons | 40.71 | 41.45 | 39.84 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 165261 | 101505 | 63756 |
| Unadjusted period prevalence (%) | 36.84 | 39.87 | 32.02 |
| Median age at first event (years) | 51.93 | 49.24 | 56.21 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_ORAL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_ORAL | 1.269 [1.12, 1.44] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 34305 out of 685157 females with K11_ORAL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_ORAL | 1.503 [1.33, 1.7] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 42746 out of 569039 males with K11_ORAL died.
Mortality risk
Mortality risk for people of age
years, who have K11_ORAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.069% | 0.251% |
| 5 | 0.513% | 1.317% |
| 10 | 1.279% | 3.188% |
| 15 | 2.524% | 5.915% |
| 20 | 4.66% | 9.621% |
Relationships between endpoints
↥Index endpoint: K11_ORAL – Diseases of oral cavity, salivary glands and jaws
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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