No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
16002 |
4. Check minimum number of eventsNone |
16002 |
5. Include endpoints |
16002 |
6. Filter based on genotype QC (FinnGen only) |
15235 |
Control definitions (FinnGen only)
Control exclude
K11_ORAL
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Diseases of pulp and periapical tissues
based on the number of shared cases.
Similar with more cases:
- Diseases of pulp and periapical tissues, including avohilmo
- Diseases of oral cavity, salivary glands and jaws
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 130540 | 58105 | 71265 |
| Only index persons | 119319 | 54293 | 65026 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.84 | 1.66 | 1.99 |
| Only index persons | 2.26 | 2.00 | 2.48 |
| Median age at first event (years) | |||
| Whole population | 47.28 | 47.78 | 47.03 |
| Only index persons | 47.71 | 48.22 | 47.29 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 15235 | 7686 | 7549 |
| Unadjusted period prevalence (%) | 3.40 | 3.02 | 3.79 |
| Median age at first event (years) | 54.73 | 52.46 | 57.04 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_PULP_PERIAPICAL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_PULP_PERIAPICAL | 2.176 [1.97, 2.41] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.14 |
During the follow-up period (1.1.1998 — 31.12.2019), 5543 out of 41677 females with K11_PULP_PERIAPICAL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_PULP_PERIAPICAL | 2.223 [2.0, 2.47] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 9404 out of 48698 males with K11_PULP_PERIAPICAL died.
Mortality risk
Mortality risk for people of age
years, who have K11_PULP_PERIAPICAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.183% | 0.389% |
| 5 | 1.238% | 2.284% |
| 10 | 2.993% | 5.893% |
| 15 | 5.855% | 11.186% |
| 20 | 10.223% | 18.764% |
Relationships between endpoints
↥Index endpoint: K11_PULP_PERIAPICAL – Diseases of pulp and periapical tissues
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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