No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
8492 |
4. Check minimum number of eventsNone |
8492 |
5. Include endpointsNone |
8492 |
6. Filter based on genotype QC (FinnGen only) |
8115 |
Control definitions (FinnGen only)
Control exclude
K11_ORAL
Extra metadata
First used in FinnGen datafreeze
DF6
Similar endpoints
↥List of similar endpoints to
Chronic periapical parodontitis
based on the number of shared cases.
Similar with more cases:
- Diseases of pulp and periapical tissues
- Dental pulpitis 1
- Dental pulpitis 4
- Diseases of pulp and periapical tissues, including avohilmo
- Diseases of oral cavity, salivary glands and jaws
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 56907 | 25599 | 30912 |
| Only index persons | 53502 | 24456 | 29046 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.80 | 0.73 | 0.86 |
| Only index persons | 1.01 | 0.90 | 1.11 |
| Median age at first event (years) | |||
| Whole population | 55.12 | 54.42 | 55.88 |
| Only index persons | 55.41 | 54.67 | 56.03 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 8115 | 3924 | 4191 |
| Unadjusted period prevalence (%) | 1.83 | 1.54 | 2.10 |
| Median age at first event (years) | 59.31 | 56.98 | 61.50 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_PARODON_PERIAPIC_CHRONIC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_PARODON_PERIAPIC_CHRONIC | 2.7 [2.39, 3.05] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.115 |
During the follow-up period (1.1.1998 — 31.12.2019), 3288 out of 20068 females with K11_PARODON_PERIAPIC_CHRONIC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_PARODON_PERIAPIC_CHRONIC | 2.78 [2.46, 3.14] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 5618 out of 23895 males with K11_PARODON_PERIAPIC_CHRONIC died.
Mortality risk
Mortality risk for people of age
years, who have K11_PARODON_PERIAPIC_CHRONIC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.208% | 0.435% |
| 5 | 1.305% | 2.79% |
| 10 | 3.499% | 6.943% |
| 15 | 6.84% | 12.42% |
| 20 | 11.978% | 20.219% |
Relationships between endpoints
↥Index endpoint: K11_PARODON_PERIAPIC_CHRONIC – Chronic periapical parodontitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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