Other diseases of lip and oral mucosa

K11_LIP_ORAL_MUCOSA

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K13
  • Hospital discharge: ICD-9 528
  • Hospital discharge: ICD-8 528
  • Hospital discharge: excluded ICD-9 5280
  • Cause of death: ICD-10 K13
  • Cause of death: ICD-9 528
  • Cause of death: ICD-8 528
  • Cause of death: excluded ICD-8 5280

2 out of 7 registries used, show all original rules.

6296

4. Check minimum number of events

None

6296

5. Include endpoints

None

6296

6. Filter based on genotype QC (FinnGen only)

6059

Control definitions (FinnGen only)

Control exclude K11_ORAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 43442 24282 18979
Only index persons 40197 22907 17290
Unadjusted period prevalence (%)
Whole population 0.62 0.70 0.53
Only index persons 0.76 0.84 0.66
Median age at first event (years)
Whole population 56.09 57.94 53.78
Only index persons 56.05 57.83 53.69

-FinnGen-

Key figures

All Female Male
Number of individuals 6059 3649 2410
Unadjusted period prevalence (%) 1.34 1.43 1.21
Median age at first event (years) 59.30 58.36 60.72

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint K11_LIP_ORAL_MUCOSA and mortality.

Females

Parameter HR [95% CI] p-value
K11_LIP_ORAL_MUCOSA 1.242 [1.13, 1.37] < 0.001
Birth year 0.994 [0.99, 1.0] 0.152

During the follow-up period (1.1.1998 — 31.12.2019), 2706 out of 17872 females with K11_LIP_ORAL_MUCOSA died.

Males

Parameter HR [95% CI] p-value
K11_LIP_ORAL_MUCOSA 1.268 [1.14, 1.41] < 0.001
Birth year 0.99 [0.98, 1.0] 0.027

During the follow-up period (1.1.1998 — 31.12.2019), 2583 out of 13078 males with K11_LIP_ORAL_MUCOSA died.

Mortality risk

Mortality risk for people of age

years, who have K11_LIP_ORAL_MUCOSA.

N-year risk Females Males
1 0.079% 0.292%
5 0.6% 1.714%
10 1.65% 3.957%
15 3.209% 7.712%
20 5.82% 13.089%

Relationships between endpoints

Index endpoint: K11_LIP_ORAL_MUCOSA – Other diseases of lip and oral mucosa

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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