Oral lichen ruber planus

K11_ORAL_LICHEN_PLANUS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K13.74
  • Cause of death: ICD-10 K13.74

2 out of 7 registries used, show all original rules.

718

4. Check minimum number of events

None

718

5. Include endpoints

None

718

6. Filter based on genotype QC (FinnGen only)

697

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF6

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3550 2602 940
Only index persons 3534 2596 938
Unadjusted period prevalence (%)
Whole population 0.06 0.07 0.03
Only index persons 0.08 0.10 0.04
Median age at first event (years)
Whole population 63.69 64.61 61.30
Only index persons 63.76 64.64 61.30

-FinnGen-

Key figures

All Female Male
Number of individuals 697 546 151
Unadjusted period prevalence (%) 0.18 0.21 0.08
Median age at first event (years) 64.74 64.42 65.88

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint K11_ORAL_LICHEN_PLANUS and mortality.

Females

Parameter HR [95% CI] p-value
K11_ORAL_LICHEN_PLANUS 0.757 [0.57, 1.01] 0.055
Birth year 0.998 [0.99, 1.01] 0.563

During the follow-up period (1.1.1998 — 31.12.2019), 87 out of 1994 females with K11_ORAL_LICHEN_PLANUS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have K11_ORAL_LICHEN_PLANUS.

N-year risk Females Males
1 0.095% No data
5 0.439% No data
10 1.153% No data
15 2.282% No data
20 4.174% No data

Relationships between endpoints

Index endpoint: K11_ORAL_LICHEN_PLANUS – Oral lichen ruber planus

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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