Other disorders of gingiva or/and edentulous alveolar ridge

K11_GINGIVA

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K06
  • Hospital discharge: ICD-9 5232
  • Hospital discharge: ICD-8 5232
  • Cause of death: ICD-10 K06
  • Cause of death: ICD-9 5232
  • Cause of death: ICD-8 5232

2 out of 7 registries used, show all original rules.

1129

4. Check minimum number of events

None

1129

5. Include endpoints

1737

6. Filter based on genotype QC (FinnGen only)

1659

Control definitions (FinnGen only)

Control exclude K11_ORAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 13283 7429 5800
Only index persons 12308 6983 5325
Unadjusted period prevalence (%)
Whole population 0.19 0.21 0.16
Only index persons 0.23 0.26 0.20
Median age at first event (years)
Whole population 52.89 53.09 52.73
Only index persons 52.86 52.99 52.69

-FinnGen-

Key figures

All Female Male
Number of individuals 1659 924 735
Unadjusted period prevalence (%) 0.37 0.36 0.37
Median age at first event (years) 56.47 53.48 60.23

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint K11_GINGIVA and mortality.

Females

Parameter HR [95% CI] p-value
K11_GINGIVA 1.525 [1.35, 1.72] < 0.001
Birth year 0.995 [0.99, 1.0] 0.259

During the follow-up period (1.1.1998 — 31.12.2019), 974 out of 6249 females with K11_GINGIVA died.

Males

Parameter HR [95% CI] p-value
K11_GINGIVA 1.822 [1.59, 2.09] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 934 out of 4898 males with K11_GINGIVA died.

Mortality risk

Mortality risk for people of age

years, who have K11_GINGIVA.

N-year risk Females Males
1 0.169% 0.308%
5 0.806% 1.93%
10 2.317% 5.249%
15 4.34% 9.737%
20 7.696% 15.974%

Relationships between endpoints

Index endpoint: K11_GINGIVA – Other disorders of gingiva or/and edentulous alveolar ridge

GWS hits: 4

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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