No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
1081 |
4. Check minimum number of eventsNone |
1081 |
5. Include endpointsNone |
1081 |
6. Filter based on genotype QC (FinnGen only) |
1032 |
Control definitions (FinnGen only)
Control exclude
K11_ORAL
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF10
Similar endpoints
↥List of similar endpoints to
Gingival hyperplasia
based on the number of shared cases.
Similar with more cases:
- Other disorders of gingiva or/and edentulous alveolar ridge
- Diseases of oral cavity, salivary glands and jaws
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7301 | 3888 | 3392 |
| Only index persons | 6866 | 3685 | 3181 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.11 | 0.09 |
| Only index persons | 0.13 | 0.14 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 51.96 | 51.28 | 52.83 |
| Only index persons | 52.67 | 52.03 | 53.42 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1032 | 516 | 516 |
| Unadjusted period prevalence (%) | 0.23 | 0.20 | 0.26 |
| Median age at first event (years) | 56.38 | 52.42 | 60.34 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_GINGIV_HYPERPLAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_GINGIV_HYPERPLAS | 1.73 [1.42, 2.1] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.069 |
During the follow-up period (1.1.1998 — 31.12.2019), 337 out of 3113 females with K11_GINGIV_HYPERPLAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_GINGIV_HYPERPLAS | 1.968 [1.6, 2.42] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 397 out of 2757 males with K11_GINGIV_HYPERPLAS died.
Mortality risk
Mortality risk for people of age
years, who have K11_GINGIV_HYPERPLAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.146% | 0.404% |
| 5 | 0.955% | 2.176% |
| 10 | 2.403% | 5.305% |
| 15 | 4.567% | 9.9% |
| 20 | 7.584% | 16.038% |
Relationships between endpoints
↥Index endpoint: K11_GINGIV_HYPERPLAS – Gingival hyperplasia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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