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Diseases of salivary glands

EFO Endpoint Browser PheWeb

K11_SALIVARY

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K11
  • Hospital discharge: ICD-9 — 527
  • Hospital discharge: ICD-8 — 527
  • Cause of death: ICD-10 — K11
  • Cause of death: ICD-9 — 527
  • Cause of death: ICD-8 — 527

2 out of 7 registries used, show all original rules.

8046

4. Check minimum number of events

None

8046

5. Include endpoints

None

8046

6. Filter based on genotype QC (FinnGen only)

7755

Control definitions (FinnGen only)

Control exclude K11_ORAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 66068 37525 28191
Only index persons 60880 35138 25742
Unadjusted period prevalence (%)
Whole population 0.95 1.07 0.79
Only index persons 1.16 1.29 0.98
Median age at first event (years)
Whole population 48.59 51.69 44.46
Only index persons 48.18 51.18 44.08

-FinnGen-

Key figures

All Female Male
Number of individuals 7755 4934 2821
Unadjusted period prevalence (%) 1.75 1.94 1.42
Median age at first event (years) 51.96 51.46 52.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_SALIVARY and mortality.

Females

Parameter HR [95% CI] p-value
K11_SALIVARY 1.205 [1.1, 1.32] < 0.001
Birth year 0.996 [0.99, 1.0] 0.279

During the follow-up period (1.1.1998 — 31.12.2019), 3897 out of 29547 females with K11_SALIVARY died.

Males

Parameter HR [95% CI] p-value
K11_SALIVARY 1.306 [1.18, 1.44] < 0.001
Birth year 0.987 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 3010 out of 21447 males with K11_SALIVARY died.

Mortality risk

Mortality risk for people of age

years, who have K11_SALIVARY.

N-year risk Females Males
1 0.117% 0.322%
5 0.728% 1.655%
10 1.79% 3.955%
15 3.436% 7.602%
20 5.984% 12.602%

Relationships between endpoints

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Index endpoint: K11_SALIVARY – Diseases of salivary glands

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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