No definition available.
Dentofacial anomalies [including malocclusion]
K11_DENTOFACIAL_ANOMALIES
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
12879 |
4. Check minimum number of eventsNone |
12879 |
5. Include endpointsNone |
12879 |
6. Filter based on genotype QC (FinnGen only) |
12377 |
Control definitions (FinnGen only)
Control exclude
K11_ORAL
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Dentofacial anomalies [including malocclusion]
based on the number of shared cases.
Similar with more cases:
- Diseases of oral cavity, salivary glands and jaws
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 104407 | 66645 | 37405 |
| Only index persons | 98819 | 63868 | 34951 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.59 | 1.91 | 1.05 |
| Only index persons | 1.99 | 2.35 | 1.33 |
| Median age at first event (years) | |||
| Whole population | 33.37 | 35.58 | 29.42 |
| Only index persons | 34.42 | 36.28 | 31.02 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 12377 | 8954 | 3423 |
| Unadjusted period prevalence (%) | 3.02 | 3.52 | 1.72 |
| Median age at first event (years) | 44.08 | 42.87 | 47.23 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_DENTOFACIAL_ANOMALIES and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_DENTOFACIAL_ANOMALIES | 0.95 [0.85, 1.06] | 0.347 |
| Birth year | 0.995 [0.99, 1.0] | 0.241 |
During the follow-up period (1.1.1998 — 31.12.2019), 2570 out of 58226 females with K11_DENTOFACIAL_ANOMALIES died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_DENTOFACIAL_ANOMALIES | 1.051 [0.94, 1.17] | 0.369 |
| Birth year | 0.986 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 1803 out of 32547 males with K11_DENTOFACIAL_ANOMALIES died.
Mortality risk
Mortality risk for people of age
years, who have K11_DENTOFACIAL_ANOMALIES.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.104% | 0.195% |
| 5 | 0.639% | 1.187% |
| 10 | 1.577% | 2.884% |
| 15 | 2.927% | 5.397% |
| 20 | 5.002% | 9.138% |
Relationships between endpoints
↥Index endpoint: K11_DENTOFACIAL_ANOMALIES – Dentofacial anomalies [including malocclusion]
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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