Open bite that required surgery (Lefort1 or BSSRO)

K11_OPEN_BITE_SURGERY

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

  • OPER_LEFORT1_BSSRO
1467

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K07.24
  • Cause of death: ICD-10 K07.24

2 out of 7 registries used, show all original rules.

312

4. Check minimum number of events

None

312

5. Include endpoints

None

312

6. Filter based on genotype QC (FinnGen only)

301

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF7

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2132 1470 646
Only index persons 2100 1460 640
Unadjusted period prevalence (%)
Whole population 0.03 0.04 0.02
Only index persons 0.04 0.05 0.02
Median age at first event (years)
Whole population 27.35 27.64 26.66
Only index persons 27.38 27.65 26.75

-FinnGen-

Key figures

All Female Male
Number of individuals 301 235 66
Unadjusted period prevalence (%) 0.08 0.09 0.03
Median age at first event (years) 30.98 30.23 33.63

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint K11_OPEN_BITE_SURGERY and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have K11_OPEN_BITE_SURGERY.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: K11_OPEN_BITE_SURGERY – Open bite that required surgery (Lefort1 or BSSRO)

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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