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Anomalies of dental arch relationship, including avohilmo

Endpoint Browser PheWeb

K11_ANOMALI_DENTAL_ARCH_RELATIONS1

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 — K07.2
  • Hospital discharge: ICD-10 — K07.2
  • Hospital discharge: ICD-9 — 5242A
  • Hospital discharge: ICD-8 — 5242
  • Cause of death: ICD-10 — K07.2
  • Cause of death: ICD-9 — 5242A
  • Cause of death: ICD-8 — 5242

3 out of 7 registries used, show all original rules.

9729

4. Check minimum number of events

None

9729

5. Include endpoints

None

9729

6. Filter based on genotype QC (FinnGen only)

9227

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF10

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 341419 171986 169161
Only index persons 273703 138640 135063
Unadjusted period prevalence (%)
Whole population 4.82 4.93 4.73
Only index persons 5.13 5.10 5.16
Median age at first event (years)
Whole population 10.43 10.52 10.30
Only index persons 11.47 11.60 11.34

-FinnGen-

Key figures

All Female Male
Number of individuals 9227 6105 3122
Unadjusted period prevalence (%) 2.12 2.40 1.57
Median age at first event (years) 27.71 28.24 26.67

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_ANOMALI_DENTAL_ARCH_RELATIONS1 and mortality.

Females

Parameter HR [95% CI] p-value
K11_ANOMALI_DENTAL_ARCH_RELATIONS1 0.772 [0.57, 1.04] 0.094
Birth year 0.995 [0.99, 1.0] 0.214

During the follow-up period (1.1.1998 — 31.12.2019), 405 out of 142641 females with K11_ANOMALI_DENTAL_ARCH_RELATIONS1 died.

Males

Parameter HR [95% CI] p-value
K11_ANOMALI_DENTAL_ARCH_RELATIONS1 0.744 [0.53, 1.04] 0.086
Birth year 0.989 [0.98, 1.0] 0.023

During the follow-up period (1.1.1998 — 31.12.2019), 467 out of 140657 males with K11_ANOMALI_DENTAL_ARCH_RELATIONS1 died.

Mortality risk

Mortality risk for people of age

years, who have K11_ANOMALI_DENTAL_ARCH_RELATIONS1.

N-year risk Females Males
1 0.079% 0.172%
5 0.387% 0.947%
10 1.06% 2.347%
15 2.066% 4.477%
20 3.76% 7.828%

Relationships between endpoints

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Index endpoint: K11_ANOMALI_DENTAL_ARCH_RELATIONS1 – Anomalies of dental arch relationship, including avohilmo

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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