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Other disorders of teeth and supporting structures

EFO Endpoint Browser PheWeb

K11_DISORD_TEETH

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K08
  • Hospital discharge: ICD-9 — 525
  • Hospital discharge: ICD-8 — 525
  • Cause of death: ICD-10 — K08
  • Cause of death: ICD-9 — 525
  • Cause of death: ICD-8 — 525

2 out of 7 registries used, show all original rules.

8878

4. Check minimum number of events

None

8878

5. Include endpoints

8878

6. Filter based on genotype QC (FinnGen only)

8508

Control definitions (FinnGen only)

Control exclude K11_ORAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 66711 32627 33639
Only index persons 62846 31242 31604
Unadjusted period prevalence (%)
Whole population 0.93 0.93 0.94
Only index persons 1.18 1.15 1.21
Median age at first event (years)
Whole population 55.57 55.55 55.75
Only index persons 55.40 55.35 55.46

-FinnGen-

Key figures

All Female Male
Number of individuals 8508 4469 4039
Unadjusted period prevalence (%) 1.88 1.76 2.03
Median age at first event (years) 58.40 55.96 61.11

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_DISORD_TEETH and mortality.

Females

Parameter HR [95% CI] p-value
K11_DISORD_TEETH 1.896 [1.71, 2.1] < 0.001
Birth year 0.995 [0.99, 1.0] 0.221

During the follow-up period (1.1.1998 — 31.12.2019), 4406 out of 26506 females with K11_DISORD_TEETH died.

Males

Parameter HR [95% CI] p-value
K11_DISORD_TEETH 2.526 [2.25, 2.83] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 6647 out of 27369 males with K11_DISORD_TEETH died.

Mortality risk

Mortality risk for people of age

years, who have K11_DISORD_TEETH.

N-year risk Females Males
1 0.16% 0.416%
5 1.089% 2.497%
10 2.747% 5.929%
15 5.399% 11.44%
20 9.018% 19.026%

Relationships between endpoints

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Index endpoint: K11_DISORD_TEETH – Other disorders of teeth and supporting structures

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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