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Stomatitis and related lesions

EFO Endpoint Browser PheWeb

K11_STOMATITIS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K12
  • Hospital discharge: ICD-9 — 5280
  • Hospital discharge: ICD-8 — 5280
  • Cause of death: ICD-10 — K12
  • Cause of death: ICD-9 — 5280
  • Cause of death: ICD-8 — 5280

2 out of 7 registries used, show all original rules.

3201

4. Check minimum number of events

None

3201

5. Include endpoints

None

3201

6. Filter based on genotype QC (FinnGen only)

3065

Control definitions (FinnGen only)

Control exclude K11_ORAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 31288 15481 15641
Only index persons 28434 14223 14211
Unadjusted period prevalence (%)
Whole population 0.44 0.44 0.44
Only index persons 0.53 0.52 0.54
Median age at first event (years)
Whole population 37.55 40.94 34.18
Only index persons 37.56 40.72 34.40

-FinnGen-

Key figures

All Female Male
Number of individuals 3065 1838 1227
Unadjusted period prevalence (%) 0.68 0.72 0.62
Median age at first event (years) 49.29 47.18 52.45

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_STOMATITIS and mortality.

Females

Parameter HR [95% CI] p-value
K11_STOMATITIS 1.717 [1.53, 1.93] < 0.001
Birth year 0.995 [0.99, 1.0] 0.245

During the follow-up period (1.1.1998 — 31.12.2019), 1822 out of 11640 females with K11_STOMATITIS died.

Males

Parameter HR [95% CI] p-value
K11_STOMATITIS 2.076 [1.82, 2.36] < 0.001
Birth year 0.984 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 1730 out of 11327 males with K11_STOMATITIS died.

Mortality risk

Mortality risk for people of age

years, who have K11_STOMATITIS.

N-year risk Females Males
1 0.105% 0.356%
5 0.945% 2.254%
10 2.146% 5.633%
15 4.477% 10.71%
20 8.265% 17.949%

Relationships between endpoints

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Index endpoint: K11_STOMATITIS – Stomatitis and related lesions

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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