No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1554 |
4. Check minimum number of eventsNone |
1554 |
5. Include endpointsNone |
1554 |
6. Filter based on genotype QC (FinnGen only) |
1476 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
First used in FinnGen datafreeze
DF6
Similar endpoints
↥List of similar endpoints to
Recurring oral aphthae
based on the number of shared cases.
Similar with more cases:
- Stomatitis and related lesions
- Recurring oral aphthae, including avohilmo
- Diseases of oral cavity, salivary glands and jaws
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 14618 | 8065 | 6494 |
| Only index persons | 12873 | 7229 | 5644 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.21 | 0.23 | 0.18 |
| Only index persons | 0.24 | 0.27 | 0.22 |
| Median age at first event (years) | |||
| Whole population | 39.85 | 46.73 | 31.25 |
| Only index persons | 40.83 | 47.06 | 32.84 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1476 | 946 | 530 |
| Unadjusted period prevalence (%) | 0.33 | 0.37 | 0.27 |
| Median age at first event (years) | 55.73 | 53.55 | 59.63 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_APHTA_RECUR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_APHTA_RECUR | 1.617 [1.45, 1.81] | < 0.001 |
| Birth year | 1.002 [0.99, 1.01] | 0.593 |
During the follow-up period (1.1.1998 — 31.12.2019), 1293 out of 7066 females with K11_APHTA_RECUR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_APHTA_RECUR | 2.015 [1.74, 2.33] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 941 out of 5520 males with K11_APHTA_RECUR died.
Mortality risk
Mortality risk for people of age
years, who have K11_APHTA_RECUR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.176% | 0.405% |
| 5 | 1.058% | 2.218% |
| 10 | 2.973% | 5.759% |
| 15 | 5.92% | 10.736% |
| 20 | 10.087% | 17.544% |
Relationships between endpoints
↥Index endpoint: K11_APHTA_RECUR – Recurring oral aphthae
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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