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Other diseases of jaws

EFO Endpoint Browser PheWeb

K11_JAWS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K10
  • Hospital discharge: ICD-9 — 526
  • Hospital discharge: ICD-8 — 526
  • Hospital discharge: excluded ICD-9 — 5260
  • Cause of death: ICD-10 — K10
  • Cause of death: ICD-9 — 526
  • Cause of death: ICD-8 — 526
  • Cause of death: excluded ICD-8 — 5260

2 out of 7 registries used, show all original rules.

2577

4. Check minimum number of events

None

2577

5. Include endpoints

None

2577

6. Filter based on genotype QC (FinnGen only)

2459

Control definitions (FinnGen only)

Control exclude K11_ORAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 18866 9953 8734
Only index persons 17132 9348 7784
Unadjusted period prevalence (%)
Whole population 0.27 0.29 0.24
Only index persons 0.32 0.34 0.30
Median age at first event (years)
Whole population 45.94 43.89 48.29
Only index persons 44.83 42.91 47.14

-FinnGen-

Key figures

All Female Male
Number of individuals 2459 1442 1017
Unadjusted period prevalence (%) 0.54 0.57 0.51
Median age at first event (years) 48.98 44.98 54.66

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_JAWS and mortality.

Females

Parameter HR [95% CI] p-value
K11_JAWS 2.015 [1.75, 2.32] < 0.001
Birth year 0.992 [0.98, 1.0] 0.129

During the follow-up period (1.1.1998 — 31.12.2019), 840 out of 6317 females with K11_JAWS died.

Males

Parameter HR [95% CI] p-value
K11_JAWS 2.349 [2.08, 2.66] < 0.001
Birth year 0.992 [0.98, 1.0] 0.082

During the follow-up period (1.1.1998 — 31.12.2019), 1205 out of 5387 males with K11_JAWS died.

Mortality risk

Mortality risk for people of age

years, who have K11_JAWS.

N-year risk Females Males
1 0.148% 0.471%
5 0.955% 2.957%
10 2.52% 7.342%
15 5.054% 14.042%
20 8.649% 23.69%

Relationships between endpoints

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Index endpoint: K11_JAWS – Other diseases of jaws

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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