retinopathy: Any disease or disorder of the retina.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
29903 |
6. Filter based on genotype QC (FinnGen only) |
28876 |
Control definitions (FinnGen only)
Control exclude
H7_CHOROIDRETINA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other retinal disorders
based on the number of shared cases.
Similar with more cases:
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 240282 | 133370 | 105652 |
| Only index persons | 214908 | 120340 | 94568 |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.43 | 3.82 | 2.95 |
| Only index persons | 4.07 | 4.42 | 3.61 |
| Median age at first event (years) | |||
| Whole population | 71.22 | 73.62 | 68.19 |
| Only index persons | 70.85 | 73.21 | 67.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 28876 | 14621 | 14255 |
| Unadjusted period prevalence (%) | 6.44 | 5.74 | 7.16 |
| Median age at first event (years) | 68.09 | 67.86 | 68.33 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_RETINALDISOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINALDISOTH | 1.057 [0.98, 1.15] | 0.176 |
| Birth year | 0.994 [0.99, 1.0] | 0.094 |
During the follow-up period (1.1.1998 — 31.12.2019), 37187 out of 112181 females with H7_RETINALDISOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINALDISOTH | 1.238 [1.12, 1.36] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 29009 out of 88934 males with H7_RETINALDISOTH died.
Mortality risk
Mortality risk for people of age
years, who have H7_RETINALDISOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.065% | 0.18% |
| 5 | 0.596% | 1.236% |
| 10 | 1.353% | 3.22% |
| 15 | 2.583% | 6.015% |
| 20 | 4.74% | 9.75% |
Relationships between endpoints
↥Index endpoint: H7_RETINALDISOTH – Other retinal disorders
GWS hits: 11
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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