Disorders of choroid and retina

H7_CHOROIDRETINA

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H30-H36
  • Cause of death: ICD-10 H30-H36

2 out of 7 registries used, show all original rules.

40552

4. Check minimum number of events

None

40552

5. Include endpoints

41359

6. Filter based on genotype QC (FinnGen only)

39949

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 336824 180991 153952
Only index persons 301178 163706 137472
Unadjusted period prevalence (%)
Whole population 4.76 5.18 4.30
Only index persons 5.67 6.02 5.25
Median age at first event (years)
Whole population 68.33 70.63 65.63
Only index persons 67.81 70.02 65.18

-FinnGen-

Key figures

All Female Male
Number of individuals 39949 20062 19887
Unadjusted period prevalence (%) 8.93 7.88 9.99
Median age at first event (years) 65.72 65.12 66.32

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint H7_CHOROIDRETINA and mortality.

Females

Parameter HR [95% CI] p-value
H7_CHOROIDRETINA 1.068 [0.99, 1.15] 0.099
Birth year 0.996 [0.99, 1.0] 0.27

During the follow-up period (1.1.1998 — 31.12.2019), 43701 out of 148951 females with H7_CHOROIDRETINA died.

Males

Parameter HR [95% CI] p-value
H7_CHOROIDRETINA 1.175 [1.07, 1.29] < 0.001
Birth year 0.986 [0.98, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 36687 out of 125413 males with H7_CHOROIDRETINA died.

Mortality risk

Mortality risk for people of age

years, who have H7_CHOROIDRETINA.

N-year risk Females Males
1 0.074% 0.166%
5 0.581% 1.254%
10 1.481% 3.047%
15 2.74% 5.855%
20 4.799% 10.282%

Relationships between endpoints

Index endpoint: H7_CHOROIDRETINA – Disorders of choroid and retina

GWS hits: 9

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data