retinopathy: Any disease or disorder of the retina.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
40552 |
4. Check minimum number of eventsNone |
40552 |
5. Include endpoints |
41359 |
6. Filter based on genotype QC (FinnGen only) |
39949 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Disorders of choroid and retina
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 336824 | 180991 | 153952 |
| Only index persons | 301178 | 163706 | 137472 |
| Unadjusted period prevalence (%) | |||
| Whole population | 4.76 | 5.18 | 4.30 |
| Only index persons | 5.67 | 6.02 | 5.25 |
| Median age at first event (years) | |||
| Whole population | 68.33 | 70.63 | 65.63 |
| Only index persons | 67.81 | 70.02 | 65.18 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 39949 | 20062 | 19887 |
| Unadjusted period prevalence (%) | 8.93 | 7.88 | 9.99 |
| Median age at first event (years) | 65.72 | 65.12 | 66.32 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_CHOROIDRETINA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHOROIDRETINA | 1.068 [0.99, 1.15] | 0.099 |
| Birth year | 0.996 [0.99, 1.0] | 0.27 |
During the follow-up period (1.1.1998 — 31.12.2019), 43701 out of 148951 females with H7_CHOROIDRETINA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHOROIDRETINA | 1.175 [1.07, 1.29] | < 0.001 |
| Birth year | 0.986 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 36687 out of 125413 males with H7_CHOROIDRETINA died.
Mortality risk
Mortality risk for people of age
years, who have H7_CHOROIDRETINA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.074% | 0.166% |
| 5 | 0.581% | 1.254% |
| 10 | 1.481% | 3.047% |
| 15 | 2.74% | 5.855% |
| 20 | 4.799% | 10.282% |
Relationships between endpoints
↥Index endpoint: H7_CHOROIDRETINA – Disorders of choroid and retina
GWS hits: 9
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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