retinal detachment: An eye emergency condition which may lead to blindness if left untreated. It is characterized by the separation of the inner retina layers from the underlying pigment epithelium. Causes include trauma, advanced diabetes mellitus, high myopia, and choroid tumors. Symptoms include sudden appearance of floaters, sudden light flushes, and blurred vision.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
14210 |
6. Filter based on genotype QC (FinnGen only) |
13719 |
Control definitions (FinnGen only)
Control exclude
H7_CHOROIDRETINA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Retinal detachments and breaks
based on the number of shared cases.
Similar with more cases:
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 113363 | 56390 | 56395 |
| Only index persons | 104387 | 52636 | 51751 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.59 | 1.62 | 1.58 |
| Only index persons | 1.96 | 1.94 | 1.98 |
| Median age at first event (years) | |||
| Whole population | 64.02 | 64.47 | 63.56 |
| Only index persons | 63.56 | 63.97 | 63.14 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 13719 | 6678 | 7041 |
| Unadjusted period prevalence (%) | 3.09 | 2.62 | 3.54 |
| Median age at first event (years) | 63.06 | 61.48 | 64.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_RETINALDETACH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINALDETACH | 1.029 [0.95, 1.12] | 0.503 |
| Birth year | 0.993 [0.99, 1.0] | 0.106 |
During the follow-up period (1.1.1998 — 31.12.2019), 9237 out of 45940 females with H7_RETINALDETACH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINALDETACH | 1.089 [1.0, 1.19] | 0.062 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 10350 out of 45205 males with H7_RETINALDETACH died.
Mortality risk
Mortality risk for people of age
years, who have H7_RETINALDETACH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.107% | 0.202% |
| 5 | 0.624% | 1.212% |
| 10 | 1.419% | 3.135% |
| 15 | 2.657% | 5.932% |
| 20 | 4.862% | 9.796% |
Relationships between endpoints
↥Index endpoint: H7_RETINALDETACH – Retinal detachments and breaks
GWS hits: 6
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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