retinal detachment: An eye emergency condition which may lead to blindness if left untreated. It is characterized by the separation of the inner retina layers from the underlying pigment epithelium. Causes include trauma, advanced diabetes mellitus, high myopia, and choroid tumors. Symptoms include sudden appearance of floaters, sudden light flushes, and blurred vision.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
4635 |
4. Check minimum number of eventsNone |
4635 |
5. Include endpointsNone |
4635 |
6. Filter based on genotype QC (FinnGen only) |
4485 |
Control definitions (FinnGen only)
Extra metadata
Similar endpoints
↥List of similar endpoints to Retinal detachment with retinal break based on the number of shared cases.
Similar with more cases:
- Retinal detachments and breaks
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 38578 | 16940 | 21396 |
Only index persons | 34930 | 15487 | 19443 |
Unadjusted period prevalence (%) | |||
Whole population | 0.55 | 0.49 | 0.60 |
Only index persons | 0.67 | 0.57 | 0.74 |
Median age at first event (years) | |||
Whole population | 61.36 | 62.21 | 60.64 |
Only index persons | 60.64 | 61.44 | 60.01 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 4485 | 1910 | 2575 |
Unadjusted period prevalence (%) | 1.06 | 0.75 | 1.29 |
Median age at first event (years) | 60.29 | 58.86 | 61.35 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_RETINALDETACHBREAK and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
H7_RETINALDETACHBREAK | 0.994 [0.91, 1.09] | 0.901 |
Birth year | 0.996 [0.99, 1.0] | 0.284 |
During the follow-up period (1.1.1998 — 31.12.2019), 2259 out of 12600 females with H7_RETINALDETACHBREAK died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
H7_RETINALDETACHBREAK | 0.965 [0.88, 1.06] | 0.442 |
Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 3077 out of 16087 males with H7_RETINALDETACHBREAK died.
Mortality risk
Mortality risk for people of age
years, who have H7_RETINALDETACHBREAK.N-year risk | Females | Males |
---|---|---|
1 | 0.104% | 0.192% |
5 | 0.655% | 1.074% |
10 | 1.597% | 2.582% |
15 | 3.115% | 5.082% |
20 | 5.255% | 8.492% |
Relationships between endpoints
↥Index endpoint: H7_RETINALDETACHBREAK – Retinal detachment with retinal break
GWS hits: 2