Retinal detachment with retinal break

H7_RETINALDETACHBREAK

retinal detachment: An eye emergency condition which may lead to blindness if left untreated. It is characterized by the separation of the inner retina layers from the underlying pigment epithelium. Causes include trauma, advanced diabetes mellitus, high myopia, and choroid tumors. Symptoms include sudden appearance of floaters, sudden light flushes, and blurred vision.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H33.0
  • Hospital discharge: ICD-9 3610
  • Hospital discharge: ICD-8 37602
  • Cause of death: ICD-10 H33.0
  • Cause of death: ICD-9 3610
  • Cause of death: ICD-8 37602

2 out of 7 registries used, show all original rules.

4635

4. Check minimum number of events

None

4635

5. Include endpoints

None

4635

6. Filter based on genotype QC (FinnGen only)

4485

Control definitions (FinnGen only)

Control exclude H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H33
Name in latin Amotio/ablatio retinae cum ruptura

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 38578 16940 21396
Only index persons 34930 15487 19443
Unadjusted period prevalence (%)
Whole population 0.55 0.49 0.60
Only index persons 0.67 0.57 0.74
Median age at first event (years)
Whole population 61.36 62.21 60.64
Only index persons 60.64 61.44 60.01

-FinnGen-

Key figures

All Female Male
Number of individuals 4485 1910 2575
Unadjusted period prevalence (%) 1.06 0.75 1.29
Median age at first event (years) 60.29 58.86 61.35

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint H7_RETINALDETACHBREAK and mortality.

Females

Parameter HR [95% CI] p-value
H7_RETINALDETACHBREAK 0.994 [0.91, 1.09] 0.901
Birth year 0.996 [0.99, 1.0] 0.284

During the follow-up period (1.1.1998 — 31.12.2019), 2259 out of 12600 females with H7_RETINALDETACHBREAK died.

Males

Parameter HR [95% CI] p-value
H7_RETINALDETACHBREAK 0.965 [0.88, 1.06] 0.442
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 3077 out of 16087 males with H7_RETINALDETACHBREAK died.

Mortality risk

Mortality risk for people of age

years, who have H7_RETINALDETACHBREAK.

N-year risk Females Males
1 0.104% 0.192%
5 0.655% 1.074%
10 1.597% 2.582%
15 3.115% 5.082%
20 5.255% 8.492%

Relationships between endpoints

Index endpoint: H7_RETINALDETACHBREAK – Retinal detachment with retinal break

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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