Traction detachment of retina

H7_RETINALDETACHTRACTION

retinal detachment: An eye emergency condition which may lead to blindness if left untreated. It is characterized by the separation of the inner retina layers from the underlying pigment epithelium. Causes include trauma, advanced diabetes mellitus, high myopia, and choroid tumors. Symptoms include sudden appearance of floaters, sudden light flushes, and blurred vision.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H33.4
  • Cause of death: ICD-10 H33.4

2 out of 7 registries used, show all original rules.

281

4. Check minimum number of events

None

281

5. Include endpoints

None

281

6. Filter based on genotype QC (FinnGen only)

270

Control definitions (FinnGen only)

Control exclude H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H33
Name in latin Ablatio retinae e tractione

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2013 939 1062
Only index persons 1790 849 941
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.03 0.03 0.04
Median age at first event (years)
Whole population 59.71 61.10 58.39
Only index persons 58.66 59.96 57.48

-FinnGen-

Key figures

All Female Male
Number of individuals 270 121 149
Unadjusted period prevalence (%) 0.06 0.05 0.07
Median age at first event (years) 53.81 51.24 55.89

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint H7_RETINALDETACHTRACTION and mortality.

Females

Parameter HR [95% CI] p-value
H7_RETINALDETACHTRACTION 1.481 [1.22, 1.8] < 0.001
Birth year 0.996 [0.99, 1.0] 0.324

During the follow-up period (1.1.1998 — 31.12.2019), 260 out of 846 females with H7_RETINALDETACHTRACTION died.

Males

Parameter HR [95% CI] p-value
H7_RETINALDETACHTRACTION 1.619 [1.36, 1.92] < 0.001
Birth year 0.99 [0.98, 1.0] 0.038

During the follow-up period (1.1.1998 — 31.12.2019), 306 out of 960 males with H7_RETINALDETACHTRACTION died.

Mortality risk

Mortality risk for people of age

years, who have H7_RETINALDETACHTRACTION.

N-year risk Females Males
1 0.144% 0.386%
5 0.809% 1.958%
10 2.047% 5.02%
15 4.393% 9.748%
20 7.447% 17.063%

Relationships between endpoints

Index endpoint: H7_RETINALDETACHTRACTION – Traction detachment of retina

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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