Other, unspecified and serous retinal detachments

H7_RETINALDETACHOTH

retinal detachment: An eye emergency condition which may lead to blindness if left untreated. It is characterized by the separation of the inner retina layers from the underlying pigment epithelium. Causes include trauma, advanced diabetes mellitus, high myopia, and choroid tumors. Symptoms include sudden appearance of floaters, sudden light flushes, and blurred vision.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H33.2, H33.5
  • Hospital discharge: ICD-9 361[8-9]
  • Hospital discharge: ICD-8 376
  • Hospital discharge: excluded ICD-8 37602
  • Cause of death: ICD-10 H33.2, H33.5
  • Cause of death: ICD-9 361[8-9]
  • Cause of death: ICD-8 376
  • Cause of death: excluded ICD-8 37602

2 out of 7 registries used, show all original rules.

972

4. Check minimum number of events

None

972

5. Include endpoints

None

972

6. Filter based on genotype QC (FinnGen only)

952

Control definitions (FinnGen only)

Control exclude H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 9905 4592 5209
Only index persons 7811 3666 4145
Unadjusted period prevalence (%)
Whole population 0.14 0.13 0.15
Only index persons 0.15 0.13 0.16
Median age at first event (years)
Whole population 59.61 61.44 58.09
Only index persons 58.28 60.41 56.39

-FinnGen-

Key figures

All Female Male
Number of individuals 952 428 524
Unadjusted period prevalence (%) 0.22 0.17 0.26
Median age at first event (years) 58.51 58.55 58.48

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint H7_RETINALDETACHOTH and mortality.

Females

Parameter HR [95% CI] p-value
H7_RETINALDETACHOTH 1.211 [1.03, 1.42] 0.018
Birth year 0.992 [0.98, 1.0] 0.08

During the follow-up period (1.1.1998 — 31.12.2019), 411 out of 2315 females with H7_RETINALDETACHOTH died.

Males

Parameter HR [95% CI] p-value
H7_RETINALDETACHOTH 1.138 [0.98, 1.33] 0.096
Birth year 0.987 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 492 out of 2585 males with H7_RETINALDETACHOTH died.

Mortality risk

Mortality risk for people of age

years, who have H7_RETINALDETACHOTH.

N-year risk Females Males
1 0.104% 0.207%
5 0.699% 1.414%
10 1.675% 3.391%
15 3.173% 6.485%
20 5.648% 10.842%

Relationships between endpoints

Index endpoint: H7_RETINALDETACHOTH – Other, unspecified and serous retinal detachments

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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