retinal detachment: An eye emergency condition which may lead to blindness if left untreated. It is characterized by the separation of the inner retina layers from the underlying pigment epithelium. Causes include trauma, advanced diabetes mellitus, high myopia, and choroid tumors. Symptoms include sudden appearance of floaters, sudden light flushes, and blurred vision.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
729 |
4. Check minimum number of eventsNone |
729 |
5. Include endpointsNone |
729 |
6. Filter based on genotype QC (FinnGen only) |
706 |
Control definitions (FinnGen only)
Control exclude
H7_CHOROIDRETINA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H33
Name in latin
Retinoschisis et cystae retinales
Similar endpoints
↥List of similar endpoints to
Retinoschisis and retinal cysts
based on the number of shared cases.
Similar with more cases:
- Retinal detachments and breaks
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5538 | 2706 | 2804 |
| Only index persons | 5192 | 2588 | 2604 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.08 |
| Only index persons | 0.10 | 0.10 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 62.82 | 63.54 | 62.17 |
| Only index persons | 62.55 | 63.27 | 61.84 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 706 | 339 | 367 |
| Unadjusted period prevalence (%) | 0.16 | 0.13 | 0.18 |
| Median age at first event (years) | 63.05 | 61.66 | 64.33 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_RETINOCHISISCYST and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINOCHISISCYST | 0.746 [0.64, 0.86] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.087 |
During the follow-up period (1.1.1998 — 31.12.2019), 279 out of 2255 females with H7_RETINOCHISISCYST died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINOCHISISCYST | 0.806 [0.7, 0.93] | 0.003 |
| Birth year | 0.988 [0.98, 1.0] | 0.016 |
During the follow-up period (1.1.1998 — 31.12.2019), 391 out of 2318 males with H7_RETINOCHISISCYST died.
Mortality risk
Mortality risk for people of age
years, who have H7_RETINOCHISISCYST.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.069% | 0.188% |
| 5 | 0.386% | 0.962% |
| 10 | 0.962% | 2.488% |
| 15 | 1.992% | 4.683% |
| 20 | 3.487% | 8.127% |
Relationships between endpoints
↥Index endpoint: H7_RETINOCHISISCYST – Retinoschisis and retinal cysts
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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