Retinal vascular occlusion

H7_RETIVASCOCCLUSION

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H34
  • Cause of death: ICD-10 H34

2 out of 7 registries used, show all original rules.

4228

4. Check minimum number of events

None

4228

5. Include endpoints

None

4228

6. Filter based on genotype QC (FinnGen only)

4066

Control definitions (FinnGen only)

Control exclude H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H30-H36
Name in latin Occlusiones vasculares retinae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 37188 18641 18366
Only index persons 34152 17322 16830
Unadjusted period prevalence (%)
Whole population 0.52 0.53 0.51
Only index persons 0.64 0.64 0.64
Median age at first event (years)
Whole population 72.34 74.37 70.25
Only index persons 71.86 73.87 69.79

-FinnGen-

Key figures

All Female Male
Number of individuals 4066 1816 2250
Unadjusted period prevalence (%) 0.94 0.71 1.13
Median age at first event (years) 69.71 69.09 70.21

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint H7_RETIVASCOCCLUSION and mortality.

Females

Parameter HR [95% CI] p-value
H7_RETIVASCOCCLUSION 1.174 [1.08, 1.28] < 0.001
Birth year 0.994 [0.99, 1.0] 0.142

During the follow-up period (1.1.1998 — 31.12.2019), 5754 out of 16475 females with H7_RETIVASCOCCLUSION died.

Males

Parameter HR [95% CI] p-value
H7_RETIVASCOCCLUSION 1.288 [1.17, 1.41] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 5940 out of 16228 males with H7_RETIVASCOCCLUSION died.

Mortality risk

Mortality risk for people of age

years, who have H7_RETIVASCOCCLUSION.

N-year risk Females Males
1 0.074% 0.199%
5 0.61% 1.392%
10 1.777% 3.547%
15 3.236% 6.767%
20 5.594% 11.494%

Relationships between endpoints

Index endpoint: H7_RETIVASCOCCLUSION – Retinal vascular occlusion

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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