Transient retinal artery occlusion

H7_RETARTOCCTRANS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H34.0
  • Cause of death: ICD-10 H34.0

2 out of 7 registries used, show all original rules.

71

4. Check minimum number of events

None

71

5. Include endpoints

None

71

6. Filter based on genotype QC (FinnGen only)

70

Control definitions (FinnGen only)

Control exclude H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H34
Name in latin Occlusio arteriae retinalis transitoria

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 494 232 259
Only index persons 457 219 238
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 69.25 71.14 67.63
Only index persons 68.72 70.55 67.03

-FinnGen-

Key figures

All Female Male
Number of individuals 70 33 37
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 63.55 60.61 66.17

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint H7_RETARTOCCTRANS and mortality.

Females

Parameter HR [95% CI] p-value
H7_RETARTOCCTRANS 1.193 [0.88, 1.61] 0.248
Birth year 0.994 [0.99, 1.0] 0.183

During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 215 females with H7_RETARTOCCTRANS died.

Males

Parameter HR [95% CI] p-value
H7_RETARTOCCTRANS 1.48 [1.11, 1.98] 0.008
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 82 out of 228 males with H7_RETARTOCCTRANS died.

Mortality risk

Mortality risk for people of age

years, who have H7_RETARTOCCTRANS.

N-year risk Females Males
1 0.125% 0.28%
5 0.736% 1.675%
10 1.684% 4.116%
15 3.186% 7.73%
20 5.643% 12.837%

Relationships between endpoints

Index endpoint: H7_RETARTOCCTRANS – Transient retinal artery occlusion

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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