No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
4357 |
6. Filter based on genotype QC (FinnGen only) |
4190 |
Control definitions (FinnGen only)
Control exclude
H7_CHOROIDRETINA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Retinal vascular disorders
based on the number of shared cases.
Similar with more cases:
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 40211 | 19929 | 20010 |
| Only index persons | 35002 | 17754 | 17248 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.56 | 0.57 | 0.56 |
| Only index persons | 0.66 | 0.65 | 0.66 |
| Median age at first event (years) | |||
| Whole population | 71.58 | 73.65 | 69.53 |
| Only index persons | 71.40 | 73.38 | 69.35 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4190 | 1852 | 2338 |
| Unadjusted period prevalence (%) | 0.98 | 0.73 | 1.17 |
| Median age at first event (years) | 69.29 | 68.87 | 69.63 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_RETINAVASC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINAVASC | 1.176 [1.08, 1.28] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.188 |
During the follow-up period (1.1.1998 — 31.12.2019), 5684 out of 16352 females with H7_RETINAVASC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINAVASC | 1.27 [1.16, 1.4] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 5848 out of 16087 males with H7_RETINAVASC died.
Mortality risk
Mortality risk for people of age
years, who have H7_RETINAVASC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.111% | 0.292% |
| 5 | 0.693% | 1.433% |
| 10 | 1.673% | 3.927% |
| 15 | 3.183% | 7.02% |
| 20 | 5.727% | 12.282% |
Relationships between endpoints
↥Index endpoint: H7_RETINAVASC – Retinal vascular disorders
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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