retinal artery occlusion: Sudden ISCHEMIA in the RETINA due to blocked blood flow through the CENTRAL RETINAL ARTERY or its branches leading to sudden complete or partial loss of vision, respectively, in the eye.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
734 |
4. Check minimum number of eventsNone |
734 |
5. Include endpointsNone |
734 |
6. Filter based on genotype QC (FinnGen only) |
698 |
Control definitions (FinnGen only)
Control exclude
H7_CHOROIDRETINA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H34
Name in latin
Aliae occlusiones arteriales retinae
Similar endpoints
↥List of similar endpoints to
Other retinal artery occlusion
based on the number of shared cases.
Similar with more cases:
- Retinal vascular disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6560 | 2771 | 3720 |
| Only index persons | 5215 | 2234 | 2981 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.08 | 0.10 |
| Only index persons | 0.10 | 0.08 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 68.13 | 69.45 | 67.22 |
| Only index persons | 68.45 | 69.76 | 67.47 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 698 | 268 | 430 |
| Unadjusted period prevalence (%) | 0.17 | 0.11 | 0.22 |
| Median age at first event (years) | 67.64 | 66.37 | 68.43 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_OTHRETARTOCC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OTHRETARTOCC | 1.324 [1.16, 1.52] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.249 |
During the follow-up period (1.1.1998 — 31.12.2019), 627 out of 1845 females with H7_OTHRETARTOCC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OTHRETARTOCC | 1.387 [1.22, 1.58] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1009 out of 2645 males with H7_OTHRETARTOCC died.
Mortality risk
Mortality risk for people of age
years, who have H7_OTHRETARTOCC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.151% | 0.239% |
| 5 | 0.758% | 1.507% |
| 10 | 1.952% | 3.968% |
| 15 | 3.719% | 7.186% |
| 20 | 6.363% | 11.684% |
Relationships between endpoints
↥Index endpoint: H7_OTHRETARTOCC – Other retinal artery occlusion
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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