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Central retinal artery occlusion

DOID EFO Endpoint Browser PheWeb

H7_CENTRRETARTOCC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H34.1
  • Hospital discharge: ICD-9 — 3623A
  • Hospital discharge: ICD-8 — 37702
  • Cause of death: ICD-10 — H34.1
  • Cause of death: ICD-9 — 3623A
  • Cause of death: ICD-8 — 37702

2 out of 7 registries used, show all original rules.

701

4. Check minimum number of events

None

701

5. Include endpoints

None

701

6. Filter based on genotype QC (FinnGen only)

677

Control definitions (FinnGen only)

Control exclude H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H34
Name in latin Occlusio arteriae centralis retinae

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6473 2574 3815
Only index persons 5023 2088 2935
Unadjusted period prevalence (%)
Whole population 0.09 0.07 0.11
Only index persons 0.10 0.08 0.11
Median age at first event (years)
Whole population 72.13 75.00 70.25
Only index persons 72.80 75.34 71.00

-FinnGen-

Key figures

All Female Male
Number of individuals 677 224 453
Unadjusted period prevalence (%) 0.18 0.09 0.23
Median age at first event (years) 70.48 70.75 70.35

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint H7_CENTRRETARTOCC and mortality.

Females

Parameter HR [95% CI] p-value
H7_CENTRRETARTOCC 1.489 [1.29, 1.71] < 0.001
Birth year 0.99 [0.98, 1.0] 0.027

During the follow-up period (1.1.1998 — 31.12.2019), 869 out of 1918 females with H7_CENTRRETARTOCC died.

Males

Parameter HR [95% CI] p-value
H7_CENTRRETARTOCC 1.483 [1.29, 1.7] < 0.001
Birth year 0.989 [0.98, 1.0] 0.015

During the follow-up period (1.1.1998 — 31.12.2019), 1259 out of 2717 males with H7_CENTRRETARTOCC died.

Mortality risk

Mortality risk for people of age

years, who have H7_CENTRRETARTOCC.

N-year risk Females Males
1 0.101% 0.298%
5 0.648% 1.86%
10 1.66% 4.71%
15 3.185% 8.66%
20 5.884% 14.684%

Relationships between endpoints

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Index endpoint: H7_CENTRRETARTOCC – Central retinal artery occlusion

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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