Retinal breaks without detachment

H7_RETINALBREAK

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H33.3
  • Hospital discharge: ICD-9 3613
  • Cause of death: ICD-10 H33.3
  • Cause of death: ICD-9 3613

2 out of 7 registries used, show all original rules.

5622

4. Check minimum number of events

None

5622

5. Include endpoints

None

5622

6. Filter based on genotype QC (FinnGen only)

5435

Control definitions (FinnGen only)

Control exclude H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H33
Name in latin Ruptura retinae sine ablatione

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 37057 20151 16809
Only index persons 36278 19857 16421
Unadjusted period prevalence (%)
Whole population 0.53 0.58 0.47
Only index persons 0.68 0.73 0.63
Median age at first event (years)
Whole population 60.88 60.16 61.81
Only index persons 60.82 60.09 61.71

-FinnGen-

Key figures

All Female Male
Number of individuals 5435 3046 2389
Unadjusted period prevalence (%) 1.20 1.20 1.20
Median age at first event (years) 61.17 59.50 63.29

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint H7_RETINALBREAK and mortality.

Females

Parameter HR [95% CI] p-value
H7_RETINALBREAK 0.725 [0.65, 0.81] < 0.001
Birth year 0.996 [0.99, 1.0] 0.329

During the follow-up period (1.1.1998 — 31.12.2019), 1190 out of 17611 females with H7_RETINALBREAK died.

Males

Parameter HR [95% CI] p-value
H7_RETINALBREAK 0.638 [0.57, 0.71] < 0.001
Birth year 0.988 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 1476 out of 14412 males with H7_RETINALBREAK died.

Mortality risk

Mortality risk for people of age

years, who have H7_RETINALBREAK.

N-year risk Females Males
1 0.062% 0.134%
5 0.415% 0.759%
10 1.058% 1.968%
15 2.039% 3.615%
20 3.557% 6.424%

Relationships between endpoints

Index endpoint: H7_RETINALBREAK – Retinal breaks without detachment

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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