No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
19415 |
4. Check minimum number of eventsNone |
19415 |
5. Include endpoints |
19415 |
6. Filter based on genotype QC (FinnGen only) |
18777 |
Control definitions (FinnGen only)
Control exclude
H7_CHOROIDRETINA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Degeneration of macula and posterior pole
based on the number of shared cases.
Similar with more cases:
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 162685 | 98760 | 63302 |
| Only index persons | 149678 | 91557 | 58121 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.41 | 2.83 | 1.77 |
| Only index persons | 2.92 | 3.37 | 2.22 |
| Median age at first event (years) | |||
| Whole population | 75.82 | 76.75 | 74.34 |
| Only index persons | 75.40 | 76.34 | 73.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 18777 | 9863 | 8914 |
| Unadjusted period prevalence (%) | 4.16 | 3.87 | 4.48 |
| Median age at first event (years) | 72.89 | 72.29 | 73.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_MACULADEGEN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_MACULADEGEN | 0.981 [0.9, 1.07] | 0.655 |
| Birth year | 0.993 [0.98, 1.0] | 0.063 |
During the follow-up period (1.1.1998 — 31.12.2019), 28261 out of 83086 females with H7_MACULADEGEN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_MACULADEGEN | 0.911 [0.83, 1.0] | 0.052 |
| Birth year | 0.995 [0.99, 1.0] | 0.213 |
During the follow-up period (1.1.1998 — 31.12.2019), 18244 out of 52547 males with H7_MACULADEGEN died.
Mortality risk
Mortality risk for people of age
years, who have H7_MACULADEGEN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.099% | 0.237% |
| 5 | 0.484% | 1.129% |
| 10 | 1.208% | 3.108% |
| 15 | 2.467% | 6.012% |
| 20 | 4.47% | 10.507% |
Relationships between endpoints
↥Index endpoint: H7_MACULADEGEN – Degeneration of macula and posterior pole
GWS hits: 11
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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