age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
716 |
4. Check minimum number of eventsNone |
716 |
5. Include endpointsNone |
716 |
6. Filter based on genotype QC (FinnGen only) |
688 |
Control definitions (FinnGen only)
Control exclude
H7_CHOROIDRETINA
Extra metadata
Level in the ICD hierarchy
5
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
H35
Similar endpoints
↥List of similar endpoints to
Macular cyst
based on the number of shared cases.
Similar with more cases:
- Degeneration of macula and posterior pole
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3939 | 2208 | 1725 |
| Only index persons | 3877 | 2177 | 1700 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.05 |
| Only index persons | 0.07 | 0.08 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 72.17 | 72.28 | 72.05 |
| Only index persons | 72.18 | 72.31 | 72.02 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 688 | 376 | 312 |
| Unadjusted period prevalence (%) | 0.15 | 0.15 | 0.16 |
| Median age at first event (years) | 72.30 | 71.75 | 72.96 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint MACULAR_CYST and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MACULAR_CYST | 0.698 [0.53, 0.92] | 0.01 |
| Birth year | 1.001 [0.99, 1.01] | 0.778 |
During the follow-up period (1.1.1998 — 31.12.2019), 119 out of 1473 females with MACULAR_CYST died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MACULAR_CYST | 0.688 [0.5, 0.94] | 0.018 |
| Birth year | 0.988 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 104 out of 1084 males with MACULAR_CYST died.
Mortality risk
Mortality risk for people of age
years, who have MACULAR_CYST.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.079% | 0.103% |
| 5 | 0.537% | 0.804% |
| 10 | 1.258% | 1.964% |
| 15 | 2.398% | 4.017% |
| 20 | 4.339% | 6.824% |
Relationships between endpoints
↥Index endpoint: MACULAR_CYST – Macular cyst
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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