No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
4747 |
4. Check minimum number of eventsNone |
4747 |
5. Include endpointsNone |
4747 |
6. Filter based on genotype QC (FinnGen only) |
4599 |
Control definitions (FinnGen only)
Control exclude
H7_CHOROIDRETINA
Extra metadata
Level in the ICD hierarchy
5
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H35
Similar endpoints
↥List of similar endpoints to
Macular pucker
based on the number of shared cases.
Similar with more cases:
- Degeneration of macula and posterior pole
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 27005 | 13935 | 13051 |
| Only index persons | 26829 | 13856 | 12973 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.38 | 0.40 | 0.36 |
| Only index persons | 0.50 | 0.51 | 0.50 |
| Median age at first event (years) | |||
| Whole population | 71.79 | 71.14 | 72.47 |
| Only index persons | 71.79 | 71.14 | 72.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4599 | 2269 | 2330 |
| Unadjusted period prevalence (%) | 1.03 | 0.89 | 1.17 |
| Median age at first event (years) | 71.49 | 69.96 | 72.97 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint MACULAR_PUCKER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MACULAR_PUCKER | 0.774 [0.65, 0.93] | 0.005 |
| Birth year | 0.995 [0.99, 1.0] | 0.204 |
During the follow-up period (1.1.1998 — 31.12.2019), 810 out of 10656 females with MACULAR_PUCKER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MACULAR_PUCKER | 0.757 [0.63, 0.92] | 0.004 |
| Birth year | 0.986 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 1119 out of 9856 males with MACULAR_PUCKER died.
Mortality risk
Mortality risk for people of age
years, who have MACULAR_PUCKER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.09% | 0.136% |
| 5 | 0.482% | 0.823% |
| 10 | 1.155% | 2.18% |
| 15 | 2.192% | 3.949% |
| 20 | 3.793% | 6.763% |
Relationships between endpoints
↥Index endpoint: MACULAR_PUCKER – Macular pucker
GWS hits: 7
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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