age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.
Dry age-related macular degeneration (includes geographic atrophy)
DOID EFO Endpoint Browser PheWeb
DRY_AMD
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
473541 |
3. Check pre-conditions, main-only, mode, registry filtersPre-conditions: EVENT_AGE>=50 Registry filters:
2 out of 7 registries used, show all original rules. |
7859 |
4. Check minimum number of eventsNone |
7859 |
5. Include endpointsNone |
7859 |
6. Filter based on genotype QC (FinnGen only) |
7589 |
Control definitions (FinnGen only)
Control exclude
H7_RETINOPATHYDIAB, H7_RETINASEPAR, MACULA_NAS, H7_GLAUCPRIMOPEN, H7_GLAUCCLOSEPRIM, H7_GLAUCSECTRAUMA, H7_GLAUCSECINFLAM, H7_GLAUCSECDISEASE, H7_GLAUCSECDRUG, H7_GLAUCNAS
Control pre-conditions
DEATH_AGE>=50
Control conditions
not DRY_AMD_EARLY
Extra metadata
Level in the ICD hierarchy
5
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H35
Name in latin
Degeneratio maculae senilis atrophica
Similar endpoints
↥List of similar endpoints to
Dry age-related macular degeneration (includes geographic atrophy)
based on the number of shared cases.
Similar with more cases:
- Age-related macular degeneration (whether dry or wet)
- Degeneration of macula and posterior pole
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 76411 | 48970 | 27076 |
| Only index persons | 68221 | 44279 | 23942 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.17 | 1.40 | 0.76 |
| Only index persons | 1.38 | 1.63 | 0.91 |
| Median age at first event (years) | |||
| Whole population | 79.61 | 80.34 | 78.29 |
| Only index persons | 79.38 | 80.14 | 77.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 7589 | 4053 | 3536 |
| Unadjusted period prevalence (%) | 1.68 | 1.59 | 1.78 |
| Median age at first event (years) | 76.58 | 76.64 | 76.51 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint DRY_AMD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRY_AMD | 0.971 [0.89, 1.06] | 0.514 |
| Birth year | 0.994 [0.99, 1.0] | 0.12 |
During the follow-up period (1.1.1998 — 31.12.2019), 18068 out of 41213 females with DRY_AMD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRY_AMD | 1.016 [0.91, 1.13] | 0.779 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 10705 out of 22693 males with DRY_AMD died.
Mortality risk
Mortality risk for people of age
years, who have DRY_AMD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.089% | 0.153% |
| 5 | 0.571% | 1.022% |
| 10 | 1.375% | 2.718% |
| 15 | 2.611% | 5.53% |
| 20 | 4.548% | 9.433% |
Relationships between endpoints
↥Index endpoint: DRY_AMD – Dry age-related macular degeneration (includes geographic atrophy)
GWS hits: 22
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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